Managing dental care for patients with thrombocytopenia presents a significant clinical challenge. The risk of bleeding complications depends not only on the platelet count and the dental or oral surgical procedure planned but also on the presence of comorbidities and other hemostasis disorders, which are often observed in patients with liver disease. The decision regarding the potential preoperative use of platelet concentrates should be made in consultation with the patient’s physician, taking into account procedural risk factors and the preoperative platelet count. Additionally, attention must be given to the risk of impaired wound healing and increased susceptibility to infection in patients receiving corticosteroid therapy and other immunosuppressive agents, as seen in patients with immune thrombocytopenic purpura.