Contrary to earlier assumptions that every dental procedure in a person with hemophilia A or B requires factor replacement therapy, it is now understood that most dental procedures can be safely performed without coagulation factor replacement, or with minimal use of it, as long as careful treatment planning is done and a hematologist is consulted. The highest risk of postoperative bleeding occurs with oral surgical and periodontal procedures. Advances in hemophilia treatment, especially prophylactic therapy, have greatly altered the disease’s natural course, improved the quality of life for affected individuals, and shaped the approach to dental care in this patient group. This chapter provides recommendations for the dental management of individuals with hemophilia, with a focus on preventing oral diseases. It highlights the use of local anesthesia and pain control in dentistry, oral surgery, and implant procedures, as well as in dental care for individuals with hemophilia and inhibitors, and those receiving emicizumab prophylaxis.