This chapter presents an integrated clinical model for combining phenol–croton peel with other modalities in a safe, sequential, and individualized manner. Based on the premise that aging is multifactorial, we describe phenol–croton as the central axis of skin quality, around which neuromodulators, fillers, biostimulators, technologies, other peels, and surgical procedures are coordinated. The principles of sequencing, guided by the chronobiology of wound healing (inflammatory phase, early and late remodeling), are detailed, highlighting temporal windows, application planes, and the avoidance of field overlap. For botulinum toxin, pre-treatment is recommended to reduce traction during healing; for fillers (HA/CaHA) and biostimulators (PLLA/PCL/diluted CaHA), later intervals are advised to increase predictability and minimize tissue reactivity. Technologies (fractional CO2/Er:YAG, RFM, Q-switched) are positioned as remote preparation or maintenance, avoiding simultaneous use in the same field. Segmental treatment with a combination of medium/superficial peels optimizes transitions and reduces systemic exposure to phenol. For acne scars, a multimodal approach (CROSS, subcision, microneedling) is proposed, alternating every 6–8 weeks to avoid breaching the skin barrier during the same phenol session. In surgical candidates, mosaic protocols and distinct stages reconcile flap perfusion with deep resurfacing. The chapter consolidates key messages on safety, personalization, and synergy, with practical tables of windows and evidence to guide decision-making.