Although phenol–croton oil peel is highly effective for skin rejuvenation, it carries both local and systemic risks that require appropriate preparation, refined technique, and the ability to intervene immediately. This chapter provides a detailed analysis of the main complications associated with the procedure, ranging from expected events such as prolonged erythema and transient hyperpigmentation to severe complications including arrhythmias, systemic toxicity, permanent scarring, and ocular changes. The pathophysiological mechanisms involved, predisposing factors, and prevention strategies based on thorough pre-procedure assessment, skin preparation, hemodynamic monitoring, and biosafety protocols are discussed. The text emphasizes the importance of distinguishing between minor adverse events, which can be managed with conservative clinical measures, and major complications that require immediate intervention, hospital support, or specialist treatment. Management algorithms are described for cardiovascular and pulmonary reactions, infections, dyschromia, and abnormal scarring, among other complications, as well as guidance for long-term follow-up and psychological support measures. By integrating prevention, early diagnosis, and structured intervention, this chapter offers a practical guide to reducing risks, ensuring greater predictability, and establishing phenol–croton oil peel as a safe procedure when performed in a qualified medical setting.