The relative absence of high-profile perpetrated bioevents is a poor predictor for the nature and imminence of the threat. Projections and surveillance based on the Intent of possible perpetrators are easily applicable, but unreliable. Minimal perpetration approaches combined with 5G-Internet assisted preparations and within-establishment operatives devalue the Intent predictor. The identification of malefactors prone to facilitate or commit such acts may be achieved by focusing not on intentions but on capabilities, a more objective predictor. Given the nature of the projected biothreats and their causality, focusing on the weak or choke points of the threat pipeline of a perpetrated event might be advantageous compared to epidemiological projections. This focus on objectively identified and assessed parameters may be achievable by AI. Wide and Narrow AI would assist in tackling Advanced biothreats in terms of risk analysis and in the planning and implementation of responses. The design of diagnostic tests and the selection of the most promising effect (thermotherapies, electrotherapies, radiotherapies) and delivery technologies (inhalable agents, bacterial/viral platforms, biohybrid microrobots and diadermal transfer by patch microneedles) and conventional, injectable and ingestible drugs, for symptomatic and causative therapy, prevention and prophylaxis shall be instrumental in an environment of unforeseen biothreats.