The facilitation of road and rail transport networks is a major facilitator of intelligent, sustainable, and human-centric movement in contemporary urban and suburban settings. Although rail transport provides capacity-efficient and energy-efficient backbone transport services, road modes offer flexibility and availability especially in first- and last-mile connectivity. The inefficiencies, more time spent on the road, more emissions and less intimate satisfaction of passengers are usually caused by the fragmented planning and functioning of these modes. Physical intermodal infrastructure coupled with digital platforms to share, plan, coordinate, and control data are some of the solutions to these challenges, which are termed Integrated Road-Rail Intelligent Transportation Systems (IRR-ITS). This chapter introduces an overall plan of road-rail systems, including system architecture, demand modeling, performance evaluation, and issues related to governance. It is focused on multimodal planning, real-time coordination, energy and emission assessment, and equity. The chapter ends with the critical issues and future research, such as the concept of digital twins of integrated corridors and scalable Mobility-as-a-Service (MaaS) ecosystems.