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The cause for hypoxemia in patients with normal ventilation is the mismatching of ventilation with perfusion in the lung. In particular, regions of either low V/Q or shunt (no ventilation) give rise to hypoxemia. The sigmoid-shaped oxygen dissociation curve explains this phenomenon. Hypoxemia is also an obligatory consequence of hypoventilation. The appropriate equations describing the link between ventilation and oxygenation are presented.

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Matching of Ventilation (V/Q) with Perfusion: Arterial Blood Gas (ABG) Analysis

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  • 发表日期：

    2026年

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  • Marc Lavietes,
  • Andrew Berman

摘要

The cause for hypoxemia in patients with normal ventilation is the mismatching of ventilation with perfusion in the lung. In particular, regions of either low V/Q or shunt (no ventilation) give rise to hypoxemia. The sigmoid-shaped oxygen dissociation curve explains this phenomenon. Hypoxemia is also an obligatory consequence of hypoventilation. The appropriate equations describing the link between ventilation and oxygenation are presented.