Salinity stress imposes imminent threat to crops worldwide, specifically around the arid and semi-arid regions. By the combined action of oxidative stress, ion toxicity, and osmotic stress, it directly impinges on seed germination and key stages of early seedling root development. Seed priming is one of the simple pre-sowing treatment applied to improve tolerance of seeds to environmental stress. This technique encompasses a variety of treatments, such as use of saline solutions (halopriming), plant hormones (hormone priming), osmotic solutions (osmopriming), or hydration of seeds in water (hydropriming). Priming techniques results in enhanced germination rate, robust seedlings, antioxidant defense, osmotic tolerance due to Na+/K+ homeostasis maintenance, membrane stability and enhanced seedling establishment in salt affected soils, which prime metabolic enzymes in the pre-germinative phase as well. The incorporation of phytohormones, osmoprotectants, or beneficial microbes into priming solutions can ameliorate stress tolerance by regulating hormonal signalling and activating stress-responsive genes. Examples include faster germination and enhanced antioxidant and stress-mediating activity in zinc-primed sorghum seeds, cerium oxide nanoparticle primed alfalfa seeds, salicylic acid primed barley and common beans, etc. This chapter highlights how diverse novel seed priming approaches trigger protective physiological and molecular responses that help plants “remember'' to mitigate stress more effectively. On a global scale, seed priming being one of the most inexpensive and eco-friendly agricultural practices may give way to sustainable farming in the salt affected areas.