Addressing the inherent limitations of conventional metallic implants—notably infection susceptibility and deficient long-term osseointegration, this study introduces a novel dual-performance platform for personalized orthopedic fixation. The geometry for the extra-articular distal humerus locking compression plate (LCP) was meticulously designed via CAD and fabricated using Digital Light Processing (DLP). The core innovation is the functionalized nanocomposite interfacial layer, which utilizes a photopolymer matrix exclusively reinforced with Titanium Dioxide (TiO2) nanoparticles. This specific formulation is designed to potentially confer essential antimicrobial properties and significantly enhance long-term osseointegration, thereby transcending the constraints of current inert implants. Nanocomposite samples were subjected to rigorous characterization, including FTIR for structural analysis and PES for assessing surface chemistry and the elemental state of Ti. Concurrently, a Finite Element Analysis (FEA) model was developed and utilized to optimize stress and strain distributions under critical biomechanical loading conditions. This integrated methodological approach establishes a robust protocol for developing a new class of personalized orthopedic implants with optimized mechanical and biological performance.