Existing literature has highlighted the harmful effects of heavy metals in soils, especially due to their transfer along the food chain from plants to humans. Plant species that have the capacity to accumulate heavy metal ions are increasingly cultivated and studied in the context of reducing soil contamination. Thus, this work mainly focuses on the assessment of heavy metal concentrations in soils from the northeastern region of Romania (Iași County), a favorable area for vegetable cultivation. For this purpose, X-ray fluorescence spectrometry (XRFS) with a Vanta 4 analyzer (Olympus, Waltham, MA, USA) was used. Also, several soil quality parameters, such as pH and organic matter content, were evaluated, considering their strong links with metal mobility and bioavailability. To better understand the transfer process from soil to plant, the residual concentrations of heavy metals were measured in both annual and perennial plants. The highest transfer factor and thus the highest capacity to accumulate heavy metals was obtained in the case of stinging nettle leaf (Urtica dioica). Based on the data obtained, stinging nettle can be considered suitable for use in soil remediation.