The article considers an important aspect of the cold spraying process – high-velocity impact of particles with a substrate. The aim is to study the effect of temperature and velocity parameters of nickel particles on their deformation during elastic-plastic impact with a titanium substrate. To study the process of impact of a single particle with a surface, numerical simulation was performed in the ABAQUS software package using the CEL method. The distribution patterns of the equivalent plastic deformation and temperature of a single nickel particle with a diameter of 25 μm upon impact with a titanium substrate were obtained. The values ​​of temperature and particle velocity during impact, used as initial conditions in the simulation, were previously obtained by gas-dynamic simulation of the low-pressure cold spraying process at gas inlet temperatures from 573.15 K to 873.15 K at a constant initial gas pressure of P0 = 1.0 MPa. The results of numerical simulations show that an increase in temperature and velocity before impact with the substrate shifts the limit of the critical velocity of particles.