This chapter examines the scientific foundations and practical challenges of linking serial homicide cases, with a particular focus on overcoming linkage blindness—the failure to identify behavioral connections across crimes committed by the same offender. This chapter begins by addressing the psychological principles that underpin behavioral consistency and distinctiveness, and how these principles are operationalized in crime scene analysis. Emphasis is placed on identifying behaviors that are salient, such as those that are observable, measurable, and meaningfully connected to the underlying psychological themes, while avoiding behaviors that are overly common or too situationally influenced to provide consistent linkage value. The chapter also addresses the critical role of analyst training, showing that effective linkage depends on practitioners’ understanding of offender psychology, behavioral salience, situational context, and methodological rigor. It concludes with a set of evidence-based recommendations for crime analysts and investigators, outlining key steps and considerations for avoiding linkage blindness and ensuring scientifically sound practice.