Humans often choose the fastest and frugal way to accomplish tasks—offenders are no exception. Decades of research have shown that crimes, including serial murders, are typically committed near the offender’s residence, with offending frequency declining as distance increases [Rossmo (Geographic profiling. CRC Press, 2000)]. Such spatial behavior patterns led to theories such as the principle of least effort, cognitive maps, routine activity, rational choice, crime pattern theory, and bounded rationality. Researchers have also leveraged these findings to develop investigative tools such as geographic profiling. This chapter reviews empirical data on home-to-crime distances and spatial patterns (e.g., distance decay), followed by theories of offender spatial decision-making, and the application of geographic profiling, with a particular focus on serial murderers.