This chapter examines the victimological dimensions of serial homicide, emphasizing the central role of victims in understanding the dynamic and decision-making processes underlying these crimes. Drawing on both classical and contemporary frameworks, it traces the evolution of victimology from early typologies centered on victim proneness and interactional responsibility to more nuanced approaches grounded in opportunity structures, situational contexts, and social inequalities. Particular attention is given to how offenders’ choices are shaped by victims’ social visibility, perceived vulnerability, and spatial environment, as well as systemic factors that make certain populations more exposed or institutionally neglected. By integrating theoretical insights from victimology with empirical findings and practical implications for investigation, this chapter contributes to a more comprehensive, victim-centered understanding of serial homicide that bridges scientific inquiry and applied practice.