Countries seek to grow and achieve sustained development, generating fierce competition for the production and commercialisation of new products and technologies. Opportunities for innovation vary greatly between countries, and the creation of knowledge and technology is unevenly distributed. This generates conflicts in the markets over intellectual property and patents. For some time now, the United Nations (UN), through the World Intellectual Property Organization (WIPO), has played a key stabilising role and faced multiple challenges in achieving the commitments of the 2030 Agenda. In the current international context, WIPO promotes regional/local capacities, diversifies innovations, works multilaterally, and generates/guides industrial ecosystems. Its role in the field of health is significant, as confirmed by its work during COVID-19 and its ongoing collaborations with the WHO and WTO on the fair distribution of patents and health technology. Finally, WIPO is relevant for UN 2.0 Action Plan, particularly in shaping a future-oriented organisational culture and strengthening the UN’s forward-looking preparedness.