This study examines the transformative role of logistics platforms and freight transport in shaping the Lisbon Metropolitan Area (LMA), emphasizing their profound impacts on urban development, economic integration, and territorial planning. Historically, Lisbon has leveraged its strategic position as a key trade gateway, evolving from a maritime hub to a sophisticated logistics and freight node. This paper highlights how modern logistics platforms, driven by globalization and digital transformation, have altered the spatial and economic fabric of Lisbon’s metropolitan region. Key issues include the growth of multimodal hubs, the rise of e-commerce, and the challenges of integrating logistics activities into sustainable urban frameworks. The research delves into the tensions between economic imperatives and urban sustainability, addressing the environmental impacts of freight transport, governance complexities, and socio-economic inequalities. Through a detailed analysis of historical developments, contemporary trends, and policy frameworks, the paper proposes strategies for balancing economic competitiveness with sustainability. Emphasis is placed on green logistics practices, regional coordination, and innovative urban planning to mitigate urban sprawl and enhance social equity. By positioning Lisbon as a critical case, the study contributes to broader discussions on the future of logistics-dependent metropolitan regions worldwide.