The need for understanding sex-specific cognitive change and need for related treatment protocols cannot be underestimated. Menopause may adversely impact cognition and mood consequent to hormonal changes such as declining estrogen. Such menopause symptoms may include forgetfulness, difficulty concentrating, as well as increased risk of depression and anxiety. These cognitive and mood changes are common during the transition to menopause but are nonprogressive and may be temporary. To manage such symptoms for women, a combination of lifestyle changes like exercise, a healthy diet, and good sleep hygiene is recommended. For more severe symptoms, medical treatments like hormone therapy or antidepressants may be helpful, and it is important to consult a healthcare professional for personalized guidance.