A Trombe wall with multi-fold glazing provides an effective solution for both heating and cooling by incorporating glazing that can fully open during the summer. However, a simple opening mechanism based on basic planning and thus may not achieve optimal system performance. Therefore, the present study focuses on regulating the opening depending on indoor environmental conditions contributing to energy saving and thermal comfort, through a more adaptive and efficient strategy, this new strategy radically confines the Trombe wall glazing based on instant conditions. The control approach will place a high priority on preserving a balance between energy efficiency and thermal comfort, taking indoor temperature and humidity into account, since improving thermal comfort while lowering energy consumption is still a major challenge. The applicability of the model is demonstrated exclusively through simulations conducted on a chalet in Longwy (France). The study models and assesses different control strategies for window and vent openings based on indoor conditions using a simulation-based approach with EnergyPlus. This is followed by simulations using Rule-Based Control in an energy management system. The rule-based control system developed led to a 90% reduction in cooling energy consumption compared to a Classic Trombe wall. The results demonstrate that implementing this system, which optimizes energy efficiency while maintaining thermal comfort, achieves approximately a 60.7% and 57.1% reduction in discomfort hours compared to the classic Trombe wall and Reference Configuration, respectively. The rule-based strategy maximizes the efficiency of the controlled multi-fold glazing Trombe while ensuring optimal thermal comfort.