This paper explores the transformative impact of digitalization on the management of perishable assets, focusing specifically on vaccine cold-chain logistics. Efficiently maintaining the integrity of vaccines from manufacturer to patient is paramount, and traditional logistics systems often face challenges in ensuring consistent temperature control, traceability, and timely delivery. We present a case study approach to investigate how digital technologies—such as IoT sensors, blockchain, cloud computing, and data analytics—can enhance visibility, accountability, and decision-making within the vaccine supply chain. The study identifies key benefits, including reduced spoilage, improved regulatory compliance, and optimized resource allocation. Furthermore, it discusses implementation challenges and proposes a framework for integrating digital solutions to create a more resilient and responsive cold-chain. The findings underscore the potential of digitalization to significantly improve public health outcomes by ensuring the safe and effective distribution of vaccines.