Developing and researching functional knitted products, especially medical compression products, is a current trend in knitwear technology. Let’s take into account the hot climatic conditions of Uzbekistan, as well as Central Asia as a whole. Two main points in this direction emerge: firstly, the demand for this type of product is increasing for the prevention of varicose veins, and secondly, consumer demand is high for an assortment of natural fibers. The article is dedicated to the research and investigation of the development of compression hosiery using natural and synthetic raw materials for hot climatic conditions. Compression knitwear variants with different fleecy knitting patterns have been developed. One of the raw materials used is cotton yarn—a natural type of raw material—and another is spandex and latex—synthetic threads. The technological parameters and physical and mechanical properties of the samples were determined. The necessary recommendations on the use of new variants of knitwear structures are offered. Samples of these structures are recommended for compression knitting products to prevent varicose veins. The scientific significance of the research results is explained by the improvement of the technology for obtaining compression hosiery products with high-quality parameters, by determining the influence of the rapports and structural elements of the fleece knitted fabric structures used in the production of compression hosiery on its technological parameters and physical-mechanical properties, and by recommending new rapports for producing compression hosiery.