Mycotic femoral artery pseudoaneurysms may present with rupture with significant blood loss. Direct arterial repair is not feasible in most instances. The patient described in this presentation had a prior above-knee amputation; therefore, arterial revascularization was not necessary for an impending rupture of a large femoral artery mycotic pseudoaneurysm. Ligation of the femoral artery without revascularization following ligation of femoral mycotic aneurysms may result in a major amputation 25–35% patients.