Green hydrogen technologies play a significant role in the transition towards clean energy systems and the achievement of global climate goals. In particular, PEM fuel cells offer a variety of potential applications in domains such as transport and energy supply. However, PEM fuel cells contain many valuable resources and materials with non-negligible ecological impacts (e.g., platinum group metals, Nafion). There is a lack of a systematic analysis for evaluating and selecting End-of-Life strategies for PEM fuel cells considering sustainability criteria. This paper aims to contribute to filling this gap and is funded by the Federal Ministry for the Environment, Nature Conservation, Nuclear Safety and Consumer Protection as part of the project “GH2GH – Green Hydrogen for Decentralised Energy Systems in Sub-Saharan Africa”. The analysis is based on an extensive literature review and interviews with experts from research, politics, and industry. Different End-of-Life strategies for PEM fuel cells are presented focusing on applicability and feasibility. In this context, several R-strategies (Repair, Reuse, Recycle, and Recover) are considered. Additionally, possible criteria for a sustainability assessment of these End-of-Life strategies are elaborated and discussed.