Scholarlink

The NADPH oxidase (NOX) protein family plays a major role in the physiology of eukaryotes by producing reactive oxygen species. Evolutionarily distant NOXs have been identified in bacterial species including Streptococcus pneumoniae. Although structurally simpler than eukaryotic counterparts, NOX from S. pneumoniae (SpNOX) shows a number of conserved characteristics, allowing it to serve as a model system. Structural, biochemical and mutagenic studies of SpNOX inform our understanding of the NOX protein family. Here, we provide a comparative analysis of bacterial and eukaryotic NOX structure. We discuss the relevant studies in the context of the major questions in NOX structure and function, including the determinants of substrate specificity and the mechanism of activation, electron transfer and hydride transfer.

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Structural and Biochemical Investigation of a Bacterial NOX from Streptococcus pneumoniae

  • 章节

  • 发表日期：

    2026年

查看全文
  • Victor R. A. Dubach,
  • Pablo San Segundo-Acosta,
  • Bonnie J. Murphy

摘要

The NADPH oxidase (NOX) protein family plays a major role in the physiology of eukaryotes by producing reactive oxygen species. Evolutionarily distant NOXs have been identified in bacterial species including Streptococcus pneumoniae. Although structurally simpler than eukaryotic counterparts, NOX from S. pneumoniae (SpNOX) shows a number of conserved characteristics, allowing it to serve as a model system. Structural, biochemical and mutagenic studies of SpNOX inform our understanding of the NOX protein family. Here, we provide a comparative analysis of bacterial and eukaryotic NOX structure. We discuss the relevant studies in the context of the major questions in NOX structure and function, including the determinants of substrate specificity and the mechanism of activation, electron transfer and hydride transfer.