This chapter discusses the relationship between spirituality and economics in a broad context. It shows that mainstream economics is a materialist and reductionist science. It criticizes the core assumptions of mainstream economics—namely, the existence of Homo EconomicusHomo Economicus and the goals of profit maximizationProfit maximization, economic efficiencyEconomic efficiency, and economic growth; and shows that these goals lead to an economy that is not only unhealthy for people but is making the planet unsustainable. The chapter makes a case for the development of a spiritually-informed economicsSpiritually-informed economics. It concludes that by helping to create ecological and human economic practices and policies, spiritually-informed economics can support the flourishing of life on Earth (both human and nonhuman, present, and future).