Disseminated intravascular coagulation (DIC) is a heterogenous group of conditions that result in inappropriate systemic intravascular activation of coagulation. The coagulopathy is always secondary to other underlying conditions such as infection, obstetric complications, and malignancy, which initiate and propagate the clotting process. Also known as “consumption coagulopathy,” DIC is manifested by a wide range of thrombotic and hemorrhagic pathology with clinical presentation ranging from subtle to catastrophic. This chapter first provides an overview of normal hemostasis including the description of blood coagulation and fibrinolysis and the regulation of these systems. Second, the complex pathophysiology of DIC is discussed including its etiology, pathogenesis, and clinical aspects. Third, the laboratory tests and the diagnosis of DIC including diagnostic scoring systems are presented. Finally, the management of DIC including anticoagulant therapy for thromboembolism and supporting treatment for bleeding complications are discussed.