This chapter explores the cultural impact and sustainable conservation practices of the Museo della Memoria e dell’Accoglienza (Museum of Memory and Welcome), located in Santa Maria al Bagno, Italy. As a case study, the museum exemplifies how local cultural institutions can act as dynamic systems interacting with their environment to foster memory, identity, and social cohesion. Drawing from a systemic perspective informed by Niklas Luhmann’s theory, the study analyzes the museum as a communicative and cultural system embedded in a broader socio-territorial environment. Particular attention is given to its role in preserving intangible cultural landscapes and mediating dissonant heritage linked to the post-WWII reception of Jewish refugees. The chapter presents a multi-dimensional methodology incorporating interviews, fieldwork, and impact indicators developed within European cultural sustainability frameworks. It evaluates the museum’s contributions to participatory governance, collective memory, and intercultural dialogue, highlighting the interplay between local communities, transnational memory networks, and institutional actors. By integrating qualitative and quantitative indicators, this analysis proposes a model for assessing the relational impact of memory institutions. The Museo della Memoria serves as an example of how cultural heritage can support sustainable development, foster inclusive narratives, and activate intergenerational and transnational bonds rooted in place-based memory.