Emerging pollutants are those accumulated products from pharmaceutical waste and other products that, due to their little regulation, are causing a significant impact on the environment and are increasingly accumulated in the environment. The effect of composting and vermicomposting on eliminating this type of emerging contaminants, specifically medicines: ibuprofen, azithromycin, ibersartan and telmisaltran, present in sewage sludge, is studied. Mixtures of these drugs were prepared with sewage sludge and rice straw residues, in proportions of 33% rice straw, 27% sewage sludge and 40% water. The samples were prepared in triplicate, placed in 32 L PVC containers (total weight 20 kg) and 500 mg.kg−1 of each of the chosen pharmaceutical products (azithromycin, ibersartan and telmisaltan, ibuprofen, caffeine and paracetamol) were added. A careful homogenization of the mixed materials was carried out, maintaining the process for 90 days. Subsequently, the worms of the Eisenia foetida type were inoculated (200 worms per container in the vermicompost, or 10 worm per kg). The moisture content was maintained at 65% throughout the period by periodic addition of water. During the composting and vermicomposting process, samples were taken on days 0, 2, 3, 5, 8, 12, 21, and 36 from the beginning. It is valued during this time, and also in the final product the moisture content and the proportion of organic C corresponding to each treatment, the total carbon and nitrogen content, the C/N ratio, and the phosphorus content are assimilable. Compost with azithromycin on day 21, both compost and vermicompost, could be considered mature (less than 10 mg O2/g ms). While the compost with antihypertensives on day 30 continued to present CO2 formation. However, in the vermicomposting process with both azithromycin and antihypertensives, differences were observed regarding maturation, reaching this on day 20 in the case of vermicompost with azithromycin and day 15 in vermicompost with antihypertensives. A follow-up is carried out during both processes of the elimination of the added drugs compared to a control. The results demonstrate the feasibility of eliminating this type of emerging contaminants using composting and vermicomposting processes, manifesting a favorable evolution of the processes. The values of temperature, pH, EC, and carbon content and nutrients obtained were adequate, within a range suitable for the life and development of the worms.