This chapter integrates insights from the preceding analyses to propose a multilayered conceptual framework for addressing digital transformation (DT) initiatives in nonprofit organizations (NPOs). This framework captures the dynamic interplay between internal preconditions, external ecosystemic influences, and mission-driven constraints. It emphasizes the iterative, nonlinear nature of DT in the nonprofit context and outlines its implications for strategy, governance, and organizational development. The chapter concludes by suggesting avenues for further research and practical recommendations for NPO leaders navigating digital change.