Biphasic Cuirass Ventilation (BCV) offers multiple ventilatory modes, including: continuous negative pressure, controlled biphasic, respiratory synchronized, high frequency chest wall oscillation (HFCWO), cough assist and cardiac synchronized mode. Each mode has specific clinical indications, allowing for a personalized approach to ventilatory support. Continuous negative pressure favors alveolar recruitment and improves oxygenation in cases of mild hypoxemia, with minimal interference in spontaneous ventilation. The controlled biphasic mode provides full ventilatory support, making it suitable for patients with absent or reduced respiratory drive. The synchronized mode offers partial support, adjusting to the patient’s spontaneous effort and promoting greater comfort and ventilatory efficiency. High-frequency chest wall oscillation (HFCWO) mobilizes secretions through rapid chest vibrations, and can be used simultaneously with ventilation. Cough assist simulates an effective cough by alternating pressures, thereby facilitating secretion clearance, reducing the need for invasive aspiration and improving alveolar ventilation. The cardiac synchronized mode aligns the ventilatory cycle with the cardiac cycle. The combination of modes in a single device makes it possible to alternate ventilatory support with airway clearance techniques, without the need to change interfaces. This chapter analyses the characteristics, applications, and benefits of the different BCV modes.