The features of seismic hazard for different spectral ordinates have been investigated for the Osmaniye region (in South-Central Turkey). The study area is characterized by a rather complex structural setting and a rather moderate level of seismic activity; still it was affected by the devastating 2023 Mw7.8 Kahramanmaraş earthquake. The probabilistic seismic hazard analysis (PSHA) has been utilized in a dense grid (~ 0.003o x 0.003°) related to 590 boreholes, the majority of which have undergone rigorous geotechnical/geophysical testing. The study has used a seismotectonic dataset including linear and areal seismic sources as well as a compiled seismicity catalog comprising the Kahramanmaraş earthquake. In order to capture the uncertainties of the seismic hazard sources, the model used a rather complex logic tree scheme, including six compatible ground motion prediction equations, three characteristic source models, three choices for earthquake recurrence parameters, and three alternatives for the maximum possible earthquake. The resultant base-PGA (the horizontal component on bedrock) with a 10% probability of exceedance in 50 years ranges between ~0.34 g in the south-western part of the city area to ~0.4 g in the north-eastern part of it. Moreover, the seismic amplification factor across the study area varies between ~ 1.0 and ~ 1.4. Based on the PSHA results, all regions of Osmaniye city are subjected to a rather high level of seismic hazard (base-acc ≥ 0.3 g). However, highest PGAs are specified on the Northern part of the city; particularly, this is highlighted in the North-eastern part of the city where it was mostly characterized with weak soils.