This study introduces a simulated design framework for Turkish reinforced concrete (RC) frame buildings that enables the generation of 3D numerical models based on the seismic design codes and construction quality effects. It integrates historical and modern Turkish seismic design regulations, including the 1975, 1998, 2007, and 2018 seismic codes, to generate RC frame building models representative of buildings constructed in different periods in Türkiye. By integrating available statistical data in the literature on local construction practices, including material properties and geometrical configurations along with the code enforcements, the framework effectively captures regional and temporal variations in building characteristics. Following the design process, it generates the OpenSees computational models that can be used to perform non-linear static and dynamic analyses, which ultimately support generating fragility functions and vulnerability models by systematically accounting for building-to-building variability. The framework’s capabilities were demonstrated through two case studies, highlighting the distinctive characteristics of the selected building classes. Overall, this framework offers a flexible, open-source environment which can support large-scale vulnerability assessments and inform risk mitigation strategies within the country.