Organ procurement organizations (OPOs) are responsible for maximizing the quality and number of organs available for transplantation. Normothermic regional perfusion (NRP) supports these goals by mitigating organ ischemic injury incurred in a donation after circulatory determination of death (DCD) donor, making it logical for OPOs to offer NRP services. OPO- and transplant center (TC)-based NRP are overlapping and complementary in maximizing donation and transplant outcomes. The surgical aspects of OPO-based NRP are the same as for TC-based NRP: efficiently establishing and maintaining DO2 for an appropriate duration are critical, and any successful NRP recovery includes proper pre-recovery planning. Potentially longer NRP duration is predictable for OPO-based NRP for multiple reasons. Minimizing pre-crossclamp dissection, an open-circuit with a blood reservoir, and blood-scavenging strategies potentially reduce the need for on-circuit packed red blood cell transfusion. There are logistical, financial, and equity-in-access benefits of OPO-based NRP. An OPO is responsible for developing a favorable donation and NRP landscape within a donation service area, which is critical to maximize the potential of NRP.