Mental health in the workplace has gained increasing relevance in occupational health, particularly in manufacturing sectors where working conditions are often demanding and repetitive. This study aimed to evaluate psycho-social risks in an Ecuadorian manufacturing company by identifying critical factors affecting workers’ psychological and emotional well-being, to propose targeted intervention strategies. A quantitative, descriptive, and cross-sectional design was employed, utilizing the Ecuadorian Ministry of Labor’s questionnaire, which was administered to a sample of 4,754 workers. Associations between sociodemographic variables and risk levels were analyzed. Results indicated that while 73% of workers were at low risk, 25% faced moderate risk, and 2% high risk. The most critical dimensions were recovery, workplace harassment, work-life conflict (double presence), and self-perceived health. The study concludes that vulnerable groups within the company require targeted interventions, which should be integrated into comprehensive occupational health and talent management programs to enhance employee well-being and organizational performance.