Navigation in humans and nonhuman animals is reliant on critical interactions between motivational-emotional systems and the hippocampus. Whereas emotions guide the navigational process to help an organism achieve the most efficient and least dangerous pathway to a reward, the hippocampus integrates sensory information and creates cognitive maps of the environment. To enable this interaction, the hippocampus is integrated into circuits that process emotions and motivation, but the precise mechanisms by which this occurs are poorly understood. One view posits that emotionally enhanced memories are better consolidated, which makes places and events associated with strong emotions easier to recall and more enduring in memory. This chapter considers how emotions and goals are intertwined within the hippocampus, and their influence on spatial maps and memories. It explores the anatomy of hippocampal circuits and their integration with cognitive, emotional, and motivational circuits, as well as hippocampal spatial representations and interactions with cognitive, emotional, and motivational processes. It examines how emotional and motivational conflict impacts the hippocampus and can disrupt hippocampal circuits, leading to emotional disorders. Throughout, future research trajectories are highlighted to fill existing knowledge gaps.