Obesity, a growing global health concern, is a significant risk factor for several chronic diseases, including non-alcoholic fatty liver disease (NAFLD), cardiovascular disorders, cancer, diabetes and immune dysfunction. Impaired metabolic regulation is often fuelled by high calorie diet and a sedentary lifestyle, which leads to excessive fat accumulation and oxidative stress. The imbalance between pro-antioxidants and antioxidants, along with chronic live tissue inflammation, aggravates the progression of NAFLD and other obesity related complications. Recent advances in nanotechnology have introduced a promising therapeutic approach using metal and metal oxide-based nanoparticles (NPs), especially those derived from underutilised medicinal plants. Strong antioxidant, anti-inflammatory and lipid-lowering qualities make these plant-mediated NPs ecofriendly and biocompatible substitute for traditional obesity treatments. The increasing relevance of plant-derived metal and metal oxide nanoparticles for the treatment of obesity and other related metabolic dysfunctions is discussed, offering a fresh, sustainable and affordable approach to this prevalent health issue.