Prostate cancer (PC) is the second most often detected cancer among men and the fifth leading cause of cancer-related deaths worldwide. In its early stages, PC is typically asymptomatic and progresses slowly, often requiring active surveillance. While no definitive protective measures have been established, certain lifestyle changes, such as increased consumption of green vegetables, reduced intake of high-fat foods, and regular physical activity, may help to lower the risk. Current satisfying approaches, predominantly allopathic (medications, radiations, and surgery), are associated with several adverse effects, including loss of muscle mass, reduced libido, and bone thinning. In light of these boundaries, research has begun to shift toward green therapeutics, utilizing plant-derived compounds for more holistic treatment strategies. However, some plant-based bioactive compounds can inadvertently induce oxidative stress by unsettling the body’s antioxidant protective system. To address this challenge, nanotechnology has developed as a promising solution. Through the improvement of bioavailability, biodegradability, half-life, and controlled release, along with protection from enzymic hydrolysis and minimizing dose-dependent toxicity reasonably, the combination of plant materials and nanotechnology surpasses the shortfalls of both plant extracts and traditional nanoparticle fabrication processes. Therefore, this chapter discovers the potential of underutilized plants and their derived metal oxide nanoparticles in the treatment of PC.