The selection of courses and topics that should constitute the basis for the natural sciences in an interdisciplinary liberal arts programme, such as the technology, liberal arts, and sciences or ATLAS at University College Twente, the Netherlands, has proven to be a non-trivial task, particularly as students develop very different profiles across the domains of social and engineering sciences. In this chapter, we propose a new design for a natural science curriculum that is not built up using traditional courses such as Thermodynamics or Newtonian Mechanics, but instead is based on the concepts of natural science. Our reasoning is that for an interdisciplinary programme, it is more important for students to learn the way of thinking of natural scientists (that is, to create a ‘beta literacy’) than just the laws, facts, and topics. To this end, we propose four basic concepts that should be leading in the design of the curriculum: systems thinking, mathematisation of phenomena, origin and hierarchy of laws, and energy. We illustrate each concept using specific topics from the natural sciences and provide a possible operationalisation (in terms of course content) for the first two semesters.