In the past, Kyrgyzstan produced up to 76,000 tons of high-quality Oriental aromatic tobacco of the Dubek type per year, which was used for natural aromatization in cigarette manufacturing. Globally, Oriental aromatic tobacco accounts for only about 8% of total production. The exceptional quality of Kyrgyz tobacco was supported by favorable high-altitude natural and climatic conditions. In Kyrgyzstan, tobacco is cultivated on small areas in the traditional tobacco-growing districts of the Osh Region (Nookat and Uzgen districts). In the Batken Region, a special variety of makhorka is grown for the production of the smokeless tobacco product nasvai. Nasvai is a type of smokeless tobacco traditionally used in Central Asia. The text presents solutions to certain challenges in mechanized post-harvest processing and fermentation technologies, using 100% solar energy, as well as approaches to unconventional uses of tobacco and tobacco waste for producing materials for medicine and industry. As part of this research, the authors conducted exploratory studies to select suitable extractants, examine the kinetics of extraction processes, assess factors influencing diffusion kinetics, and separate group fractions of tobacco raw materials and waste into individual components. A conceptual process diagram has been developed for the primary processing of freshly harvested tobacco stems, along with a proposed scheme for the integrated processing of tobacco raw materials and a technological line for obtaining protein and processed tobacco stems.