Pharmaceutical drugs are emerging pollutants of great interest that are present in surface water, groundwater, even in drinking water and, in low concentrations, can negatively affect flora, fauna and human health. The main objective of this research was to demonstrate the ability of Eichhornia crassipes to remove mixtures of highly prescribed and over-the-counter drugs in aqueous medium. In the dissolution mixture of the two study drugs, Eichhornia crassipes removed 99.6% of diclofenac and ciprofloxacin in the first 24 h, finally obtaining 99.9% removal of these drugs at 96 h of the experiment. In the dissolution mixture of the five study drugs, Eichhornia crassipes removed 93.3% of acetaminophen in the first 24 h, while in the same experimental time it removed more than 98% of ibuprofen, sulfamethoxazole, ciprofloxacin and diclofenac. At the end of the experiment at 96 h, 99.7% removal of diclofenac was obtained, this being the highest percentage of removal of this drug mixture p < 0.0500. These results confirm that Eichhornia crassipes presented high efficiency in the removal of mixtures in aqueous medium from the study drugs, manifesting its potential as a sustainable alternative for the treatment of wastewater contaminated with pharmaceutical drugs.