The increasing pressure on local, regional and global ecological processes has created a strong impetus to mitigate the drivers of human induced climate change. Given the magnitude of their impacts, a sustainable future is unattainable without transforming buildings. The Life Cycle Assessment (LCA) framework has been widely adopted to promote low carbon building design. However, as no environmental issue exists in isolation, minimising carbon without considering the systemic interactions between environmental impacts can create unintended consequences. Therefore, assessments need to account for impacts beyond carbon as well. This study assesses all impacts of the European regulated LCA framework for two residential case study buildings in London. The analysis is contextualised within the dynamic effects of climate change and grid decarbonisation that will affect buildings throughout their lifecycle. Results reveal key performance differences incidental to each building’s distinct material and MEP characteristics. Whilst climate change was found to reduce heating demand in both cases, it does not in itself reduce operational energy consumption if active cooling is provided. As for grid decarbonisation, several co-benefits can be claimed across most impacts. However, depending on the composition of UK’s electricity mix there might be a burden shifting to land use. Overall, identifying patterns and similar trends for impacts beyond carbon in light of climate change and grid decarbonisation remains challenging.