Seafood, known for its nutritional value, poses environmental, ethical and health concerns. Increased consumption of animal-based foods, including seafood, poses a threat to the ecosystem due to rising greenhouse gas emissions, biodiversity loss, illnesses and harmful metals from water pollution. This has raised consumer awareness of the importance of using seafood analogs to ensure a sustainable future. Plant-based diets have gained popularity in response to environmental, health, religious, ethical and animal welfare issues. Food safety for plant-based foods should be prioritized over processing and nutrition. Plant-based foods may contain various food safety risks at different phases of production. Recognizing and identifying potential risk concerns in plant-based foods are important for both human health and the sustainable growth of new companies. Research on the potential food safety risks associated with these seafood plant-based sources is not well-documented. In this chapter, we emphasize recent progress in understanding the safety, labelling and regulations of seafood analogs, which have remained difficult to address in the development of plant-based foods. This chapter has identified several research gaps that should be addressed to inform the future development and commercialization of plant-based seafood. Further research, technological advancements, food standards, risk assessment and a multidisciplinary approach are crucial to address safety concerns and promote the responsible development and use of new-generation plant-based seafood analogs, particularly for emerging foods with limited understanding of their risks and benefits.