Over the past few years, supply chain professionals have contended with an unparalleled series of disruptions. A convergence of global phenomena—including the COVID-19 pandemic, escalating geopolitical tensions, and economic volatility—has triggered persistent and wide-ranging disturbances across international supply networks. The functionality of global value chains has been compromised to an extent arguably more severe than at any point since their inception, exposing critical vulnerabilities and prompting a reevaluation of conventional supply chain strategies. In order to continue operating in the current environment, supply chains need to balance between flexibility and redundancy. This has increased the relevance of lean resilience, a recent concept which seems to be a promising direction in addressing these challenges. Considering this novel situation, we find that there is a need for an up-to-date supply chain resilience framework that could provide supply chain experts and policymakers with a structured approach to building resilient and robust supply chains and navigating the new normal. By analyzing and synthesizing the previous literature, we provide an overview of the strategic challenges faced by today’s supply chains and discuss the premises for supply chain resilience. Based on this analysis and discussion, we then propose a conceptual framework and further detail its elements, including risk detection and estimation, company-level means for ensuring resilience, and increasing visibility. We also include dependency identification and understanding power positions as parts of the framework, as they seem to be less discussed in previous supply chain resilience frameworks, though should be considered important elements of resilience due to the growing complexity and interconnectedness of supply chains.