This research examined the relationship between innovative activities or those that the company carries out to achieve innovation and sustainability-oriented process innovation in Chilean agricultural companies. The research is quantitative and uses data from the Chilean national survey of innovation activities, the data processing was performed using the Probit regression model. The results indicate that the innovative activities: internal R&D, external R&D and training for innovation are the activities that are positively related to process innovation in these companies. The research has theoretical implications since it allows us to understand the innovative strategies and activities that companies in the agricultural sector have carried out and that lead to sustainability-oriented process innovation, specifically developing internal and external R&D and training for innovation. The research has practical implications for managers and administrators of agricultural companies who can take advantage of this knowledge to implement agricultural practices and innovative activities to lead their companies towards sustainability-oriented process innovation.