Ivy gourd (Coccinia grandis) is valued in cuisines and traditional medicines for addressing hyperglycaemia, inflammation, and various health conditions. This chapter details nutrient composition, therapeutic values alongside post-harvest techniques and value addition. Structural organization encompasses comprehensive nutrient profiling, multifaceted therapeutic benefits and bioactive constituent mapping. Post-harvest handling and preservation techniques, diversified processing methodologies and value-addition strategies encompassing pre-treatment and drying optimization, vegetable preparation protocols, spiced culinary preparations, pickle formulation, juice processing, baked foods integration and specialized product development from alternative plant components are also described in the chapter. It is noted that market expansion and commercialization pathways for innovative ivy gourd products can be identified and pursued by the professionals and researchers through this chapter.