Limb deficiencies in children require lifelong, individualized management and present unique challenges due to the dynamic nature of growth and development. A multidisciplinary approach can minimize time, reduce costs, and optimize outcomes. Opportunities to enhance value include, in some cases, forgoing prosthetic use altogether, selecting activity-specific prostheses, implementing a staged introduction and management plan, and using 3D-printed transitional prostheses for upper extremity deficiencies. For some children with lower limb deficiencies, amputation followed by prosthetic rehabilitation may offer advantages over limb lengthening; however, this decision must be carefully individualized. Supportive environments, peer-to-peer connections, and prosthesis use can all contribute positively to a child’s adjustment and self-image. A focus on psychological well-being and overall quality of life is key. In addition, education and emotional support for parents are crucial and benefit both the parents and the child. Clinicians must be well-versed in the unique needs of this population and consider the strategies outlined in the current chapter to improve value.