The history of computing in India started with the pioneering efforts of Professor Prasanta Chandra Mahalanobis at the Indian Statistical Institute (ISI). This paper explores the significant role ISI played in introducing, developing, and advancing computing technology in India. Beginning with early mechanical and electromechanical computing machines, ISI spearheaded the fabrication of indigenous computing devices and the installation of digital computers. Over the decades, ISI has remained at the forefront of computational research, contributing to areas such as pattern recognition, machine learning, artificial intelligence, and soft computing. This paper explores the evolution of computing at ISI, highlighting its contributions to India’s technological advancements and its lasting impact on computational research and education. This paper explores the evolution of computing at ISI, highlighting its contributions to India’s technological advancements and its lasting impact on computational research and education, underscoring India’s place in the global development of computing and by offering valuable insights into the international history of computing.