This final chapter brings together the book’s central themes by considering how prevention and reduction can reshape the missing persons landscape. It argues that prevention requires coordination across policing, health, housing, and social care rather than reliance on law enforcement alone. Using the framework of primary, secondary, and tertiary prevention, the chapter illustrates how early interventions, rapid response systems, and post-incident supports can reduce disappearance, harm, and recurrence. Examples from Canada, the US, the UK, Aotearoa New Zealand, and the Netherlands demonstrate how prevention can be implemented in practice. The chapter concludes by reframing missing persons as a collective responsibility and by emphasizing the need to translate knowledge into sustained, system-level change. It calls for integrated, evidence-informed strategies that strengthen coordination across sectors, embed prevention as a core practice, and cultivate the conditions in which fewer people go missing.