The main ejaculatory disorders are premature ejaculation, delayed ejaculation and retrograde ejaculation. The commonest disorder, premature ejaculation, has two licensed agents with proven efficacy and good tolerability: a local anaesthetic prilocaine/lidocaine spray and an orally active, on demand, selective serotonin reuptake inhibitor, dapoxetine. Delayed ejaculation and anorgasmia have no pharmacological management options whilst retrograde ejaculation due to neurogenic bladder neck dysfunction may be helped by sympathomimetic agents. Whilst there is a plethora of agents available for all ejaculatory disorders, most are unlicensed and have varying degrees of evidence to support their use.

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Ejaculatory Disorders

  • Ian Eardley

摘要

The main ejaculatory disorders are premature ejaculation, delayed ejaculation and retrograde ejaculation. The commonest disorder, premature ejaculation, has two licensed agents with proven efficacy and good tolerability: a local anaesthetic prilocaine/lidocaine spray and an orally active, on demand, selective serotonin reuptake inhibitor, dapoxetine. Delayed ejaculation and anorgasmia have no pharmacological management options whilst retrograde ejaculation due to neurogenic bladder neck dysfunction may be helped by sympathomimetic agents. Whilst there is a plethora of agents available for all ejaculatory disorders, most are unlicensed and have varying degrees of evidence to support their use.