Tetracyclines are a cornerstone in managing urological infections due to their broad-spectrum activity and excellent penetration into urogenital tissues. Effective against Gram-positive and Gram-negative bacteria, they are particularly valuable in urinary tract infections (UTIs) and sexually transmitted infections (STIs). Doxycycline is a second-generation tetracycline and remains widely used for its efficacy, oral route availability and suitability in renal impairment. They are contraindicated in pregnancy and children under the age of 8.