Urinary tract infections (UTIs) are a common cause of mortality and morbidity. UTIs are classified as uncomplicated or complicated. Uncomplicated are infections in non-pregnant, immunocompetent women with no known anatomical or functional abnormalities. Complicated UTIs include UTIs in men, pregnancy, immunocompromised hosts, and in those with a structural or functional renal tract abnormality. Complicated UTIs are associated with higher rates of treatment failure. The incidence of UTIs caused by multi-drug resistant organisms is increasing, highlighting the importance of good antimicrobial stewardship. As well as targeted and antimicrobials, successful treatment of UTIs include adequate source control e.g. drainage of renal abscess and removal of urinary catheter where possible. In recurrent UTIs, a multi-faceted management approach is required with other supportive measures, in addition to pharmacological options.